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BU KİTAP İÇİN ÖN SİPARİŞ ALINMAKTADIR. TESLİM SÜRESİ 6 - 8 HAFTADIR. BİLGİ ALMAK İÇİN MAĞAZAMIZI ARAYINIZ
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A favorite text of physiology students worldwide, Guyton and Hall Textbook of Medical Physiology delivers the complex knowledge you need to master in a distinctive, easy-to-digest format. The fifteenth Edition of this bestselling text is fully up to date and provides clear, comprehensive coverage of the content most relevant to clinical and pre-clinical students. The unique format ensures maximum learning and retention of complex concepts: a larger font size emphasizes core information, while supporting information is detailed in a smaller font and highlighted in pale blue―making it easy to quickly skim the essential text or pursue more in-depth study.
| Table Of Contents: | ||
| UNIT I Introduction to Physiology: The Cell and General Physiology 1. Functional Organization of the Human Body and Control of the “Internal Environment” Cells Are the Living Units of the Body Extracellular Fluid—The “Internal Environment” Homeostasis—Maintenance of a Stable Internal Environment Control Systems of the Body Physiological Variability Sex Differences in Physiology and Pathophysiology Summary—Automaticity of the Body 2. The Cell and Its Functions Organization of the Cell Cell Structure Functional Systems of the Cell Locomotion of Cells 3. Genetic Control of Protein Synthesis, Cell Function, and Cell Reproduction Cell Nucleus Genes Control Protein Synthesis Transcription—Transfer of Cell Nucleus DNA Code to Cytoplasm RNA Code Translation—Formation of Proteins on the Ribosomes Protein Enzymes Control Synthesis of Other Substances in the Cell Regulation of Gene Function and Biochemical Activity in Cells The DNA–Genetic System Controls Cell Reproduction Cell Differentiation Apoptosis—Programmed Cell Death Cancer UNIT II Membrane Physiology, Nerve, and Muscle 4. Transport of Substances Through Cell Membranes The Cell Membrane Is a Lipid Bilayer With Cell Membrane Transport Proteins Diffusion Active Transport of Substances Through Membranes 5. Membrane Potentials and Action Potentials Basic Physics of Membrane Potentials Resting Membrane Potential of Neurons Neuron Action Potential Propagation of the Action Potential Importance of Energy Metabolism for Reestablishing Sodium and Potassium Ionic Gradients After Action Potentials Are Completed Plateau in Some Action Potentials Rhythmicity of Some Excitable Tissues—Repetitive Discharge Special Characteristics of Signal Transmission in Nerve Trunks Excitation—The Process of Eliciting the Action Potential 6. Contraction of Skeletal Muscle Physiological Anatomy of Skeletal Muscle General Mechanism of Muscle Contraction Molecular Mechanisms of Muscle Contraction Energetics of Muscle Contraction Characteristics of Whole Muscle Contraction 7. Excitation of Skeletal Muscle: Neuromuscular Transmission and Excitation-Contraction Coupling Neuromuscular Junction and Transmission of Impulses From Nerve Endings to Skeletal Muscle Fibers Muscle Action Potential Excitation-Contraction Coupling 8. Excitation and Contraction of Smooth Muscle Contraction of Smooth Muscle Regulation of Contraction By Calcium Ions Nervous and Hormonal Control of Smooth Muscle Contraction UNIT III: The Heart 9. Cardiac Muscle; The Heart as a Pump and Function of the Heart Valves Cardiac Muscle Physiology The Cardiac Cycle Regulation of Heart Pumping 10. Rhythmical Excitation of the Heart Specialized Excitatory and Conductive System of the Heart Control of Excitation and Conduction in the Heart 11. Fundamentals of Electrocardiography Waveforms of the Normal Electrocardiogram Flow of Current Around the Heart During the Cardiac Cycle Electrocardiographic Leads 12. Electrocardiographic Interpretation of Cardiac Muscle and Coronary Blood Flow Abnormalities: Vectorial Analysis Vectorial Analysis of Electrocardiograms Vectorial Analysis of the Normal Electrocardiogram Mean Electrical Axis of the Ventricular QRS and Its Significance Conditions That Cause Abnormal Voltages of the QRS Complex Prolonged and Bizarre Patterns of the QRS Complex Current of Injury on the Electrocardiogram Abnormalities in the T Wave 13. Cardiac Arrhythmias and Their Electrocardiographic Interpretation Abnormal Sinus Rhythms Heart Block Within the Intracardiac Conduction Pathways Premature Contractions Paroxysmal Tachycardia Ventricular Fibrillation Atrial Fibrillation Atrial Flutter Cardiac Arrest UNIT IV: The Circulation 14. Overview of the Circulation: Pressure, Flow, and Resistance Physical Characteristics of the Circulation Basic Principles of Circulatory Function Interrelationships of Pressure, Flow, and Resistance 15. Vascular Distensibility and Functions of the Arterial and Venous Systems Vascular Distensibility Arterial Pressure Pulsations Veins and Their Functions 16. The Microcirculation and Lymphatic System: Capillary Fluid Exchange, Interstitial Fluid, and Lymph Flow Structure of the Microcirculation and Capillary System Vasomotion Causes Intermittent Capillary Blood Flow Exchange of Substances Between the Blood and Interstitial Fluid Interstitium and Interstitial Fluid Fluid Filtration Across Capillaries Lymphatic System 17. Local and Humoral Control of Tissue Blood Flow Local Blood Flow Is Controlled in Response to Tissue Needs Mechanisms of Local Blood Flow Control Humoral Control of the Circulation 18. Nervous Regulation of the Circulation and Rapid Control of Arterial Pressure Nervous Regulation of the Circulation Special Features of Nervous Control of Arterial Pressure 19. Role of the Kidneys in Long-Term Control of Arterial Pressure and in Hypertension: The Integrated System for Arterial Pressure Regulation Renal–Body Fluid System for Arterial Pressure Control Role of the Renin-Angiotensin System in Arterial Pressure Control Summary of Integrated Multifaceted Systems for Arterial Pressure Regulation 20. Cardiac Output, Venous Return, and Their Regulation Normal Values for Cardiac Output at Rest and During Activity Control of Cardiac Output By Venous Return—Frank-Starling Mechanism of the Heart Methods for Measuring Cardiac Output 21. Muscle Blood Flow and Cardiac Output During Exercise; The Coronary Circulation and Ischemic Heart Disease Blood Flow Regulation in Skeletal Muscle at Rest and During Exercise Coronary Circulation 22. Heart Failure Circulatory Dynamics in Heart Failure Unilateral Left Heart Failure Low-Output Cardiac Failure—Cardiogenic Shock Edema in Patients With Heart Failure Cardiac Reserve Quantitative Graphic Analysis of Cardiac Failure Heart Failure With Preserved Ejection Fraction High-Output Heart Failure 23. Heart Valves and Heart Sounds; Valvular and Congenital Heart Defects Heart Sounds Abnormal Circulatory Dynamics in Valvular Heart Disease Abnormal Circulatory Dynamics in Congenital Heart Defects Use of Extracorporeal Circulation During Cardiac Surgery Hypertrophy of the Heart in Valvular and Congenital Heart Disease 24. Circulatory Shock and Its Treatment Physiological Causes of Shock Hypovolemic Shock Due to Hemorrhage Distributive Shock Is Characterized By Severe Peripheral Vasodilation Obstructive Shock Is Usually Due to Noncardiac Causes of Reduced Cardiac Output Physiology of Treatment in Shock Circulatory Arrest UNIT V: The Body Fluids and Kidneys 25. Regulation of Body Fluid Compartments: Extracellular and Intracellular Fluids; Edema Intake and Output of Fluids and Solutes Are Balanced During Long-Term Steady-State Conditions Body Fluid Compartments Constituents of Extracellular and Intracellular Fluids Measurement of Body Fluid Component Volumes—Indicator-Dilution Principle Fluid Exchange and Osmotic Equilibrium Between Intracellular and Extracellular Fluid Volume and Osmolality of Extracellular and Intracellular Fluids in Abnormal States Glucose and Other Solutions Administered for Nutritive Purposes Clinical Abnormalities of Fluid Volume Regulation: Hyponatremia and Hypernatremia Edema: Excess Fluid in the Tissues Fluids in Potential Spaces of the Body 26. The Urinary System: Functional Anatomy and Urine Formation By the Kidneys Multiple Functions of the Kidneys Physiological Anatomy of the Kidneys Urine Formation Results From Glomerular Filtration, Tubular Reabsorption, and Tubular Secretion Micturition 27. Glomerular Filtration, Renal Blood Flow, and Their Control Glomerular Filtration—The First Step in Urine Formation Determinants of GFR Renal Blood Flow Physiological Control of GFR and Renal Blood Flow Autoregulation of GFR and Renal Blood Flow 28. Renal Tubular Reabsorption and Secretion Tubular Reabsorption Is Quantitatively Large and Highly Selective Tubular Reabsorption Includes Passive and Active Mechanisms Reabsorption and Secretion Along Different Parts of the Nephron Regulation of Tubular Reabsorption Use of Clearance Methods to Quantify Kidney Function 29. Urine Concentration and Dilution; Regulation of Extracellular Fluid Osmolarity and Sodium Concentration Kidneys Excrete Excess Water By Forming Dilute Urine Kidneys Conserve Water By Excreting Concentrated Urine Countercurrent Multiplier Mechanism Control of Extracellular Fluid Osmolarity and Sodium Concentration 30. Renal Regulation of Potassium, Calcium, Phosphate, and Magnesium; Integration of Renal Mechanisms for Control of Blood Volume and Extracellular Fluid Volume Regulation of Internal Potassium Distribution Regulation of Renal Potassium Excretion Regulation of Renal Calcium Excretion and Extracellular Calcium Ion Concentration Regulation of Renal Phosphate Excretion Regulation of Renal Magnesium Excretion and Extracellular Magnesium Ion Concentration Integration of Renal Mechanisms for Control of Extracellular Fluid Distribution of Extracellular Fluid Between Interstitial Spaces and Vascular System Nervous and Hormonal Factors Increase Effectiveness of Renal–Body Fluid Feedback Control Integrated Responses to Changes in Sodium Intake Conditions That Cause Large Increases in Blood Volume and Extracellular Fluid Volume Conditions That Cause Large Increases in Extracellular Fluid Volume With Normal or Reduced Blood Volume 31. Acid–Base Regulation Hydrogen Ion Concentration Is Precisely Regulated Acids and Bases—Definitions and Meanings Defending Against Changes in H+ Concentration: Buffers, Lungs, and Kidneys Buffering of H+ in the Body Fluids Bicarbonate Buffer System Phosphate Buffer System Proteins Are Important Intracellular Buffers Respiratory Regulation of Acid–Base Balance Renal Control of Acid–Base Balance Secretion of H+ and Reabsorption of HCO3− By the Renal Tubules Combination of Excess H+ With Phosphate and Ammonia Buffers in the Tubule Generates “New” HCO3− Quantifying Renal Acid–Base Excretion Regulation of Renal Tubular H+ Secretion Renal Correction of Acidosis—Increased Excretion of H+ and Addition of HCO3− to the Extracellular Fluid Renal Correction of Alkalosis—Decreased Tubular Secretion of H+ and Increased Excretion of HCO3− 32. Diuretics and Kidney Diseases Diuretics and Their Mechanisms of Action Kidney Diseases Acute Kidney Injury CKD Is Often Associated With Irreversible Loss of Functional Nephrons UNIT VI: Blood Cells, Immunity, and Blood Coagulation 33. Red Blood Cells, Anemia, and Polycythemia Red Blood Cells (Erythrocytes) Iron Metabolism Anemias Polycythemia 34. Resistance of the Body to Infection: I. Leukocytes, Granulocytes, the Monocyte-Macrophage System, and Inflammation Leukocytes (White Blood Cells) Neutrophils and Macrophages Defend Against Infections Monocyte-Macrophage Cell System (Reticuloendothelial System) Inflammation: Role of Neutrophils and Macrophages Eosinophils Basophils Leukopenia Leukemias 35. Resistance of the Body to Infection: II. Immunity and Allergy Acquired (Adaptive) Immunity Allergy and Hypersensitivity Sex Differences in Innate and Adaptive Immunity 36. Blood Types, Transfusion, and Tissue and Organ Transplantation Antigenicity Causes Immune Reactions of Blood O-A-B Blood Types Rh Blood Types Transfusion Reactions Resulting From Mismatched Blood Types Transplantation of Tissues and Organs 37. Hemostasis and Blood Coagulation Hemostasis Events Mechanism of Blood Coagulation Conditions That Cause Excessive Bleeding in Humans Thromboembolic Conditions Anticoagulants for Clinical Use Blood Coagulation Tests UNIT VII: Respiration 38. Pulmonary Ventilation Mechanics of Pulmonary Ventilation Pulmonary Volumes and Capacities Alveolar Ventilation 39. Pulmonary Circulation, Pulmonary Edema, and Pleural Fluid Physiological Anatomy of the Pulmonary Circulatory System Pressures in the Pulmonary Circulatory System Blood Volume of the Lungs Blood Flow Through the Lungs and Its Distribution Effect of Hydrostatic Pressure Gradients in the Lungs on Regional Pulmonary Blood Flow Pulmonary Capillary Dynamics Fluid in the Pleural Cavity 40. Principles of Gas Exchange; Diffusion of Oxygen and Carbon Dioxide Through Respiratory Membranes Compositions of Alveolar Air and Atmospheric Air Are Different Diffusion of Gases Through the Respiratory Membrane 41. Transport of Oxygen and Carbon Dioxide in Blood and Tissue Fluids Transport of Oxygen From the Lungs to the Body Tissues Transport of CO2 in Blood Respiratory Exchange Ratio 42. Regulation of Respiration Respiratory Center Chemical Control of Respiration Peripheral Chemoreceptor System—Role of Oxygen in Respiratory Control Regulation of Respiration During Exercise 43. Respiratory Insufficiency—Pathophysiology, Diagnosis, Oxygen Therapy Methods for Studying Respiratory Abnormalities Pathophysiology of Specific Pulmonary Abnormalities Hypoxia and Oxygen Therapy Hypercapnia—Excess Carbon Dioxide in the Body Fluids Respiratory Resuscitation and Mechanical Ventilators UNIT VIII: Aviation, Space, and Deep-Sea Diving Physiology 44. Aviation, High Altitude, and Space Physiology Effects of Low Oxygen Pressure on the Body 45. Physiology of Deep-Sea Diving and Other Hyperbaric Conditions Effect of High Partial Pressures of Individual Gases on the Body Self-Contained Underwater Breathing Apparatus (SCUBA) Diving UNIT IX: The Nervous System: A. General Principles and Sensory Physiology 46. Organization of the Nervous System, Basic Functions of Synapses and Neurotransmitters General Design of the Nervous System Major Levels of Central Nervous System Function Comparison of the Nervous System to a Computer Central Nervous System Synapses Special Characteristics of Synaptic Transmission 47. Sensory Receptors and Neuronal Circuits for Processing Information Types of Sensory Receptors and the Stimuli They Detect Transduction of Sensory Stimuli Into Nerve Impulses Signal Intensity Transmission in Nerve Tracts—Spatial and Temporal Summation Transmission and Processing of Signals in Neuronal Pools Instability and Stability of Neuronal Circuits 48. Somatic Sensations: I. General Organization, Tactile and Position Senses Classification of Somatic Senses Detection and Transmission of Tactile Sensations Sensory Pathways for Transmitting Somatic Signals Into the Central Nervous System Transmission in the Dorsal Column–Medial Lemniscal System Transmission of Sensory Signals in the Anterolateral Pathway 49. Somatic Sensations: II. Pain, Headache, and Thermal Sensations Fast Pain and Slow Pain and Their Qualities Pain Receptors (Nociceptors) and Their Stimulation Dual Pathways for Transmission of Pain Signals Into the Central Nervous System Pain Suppression (Analgesia) System in the Brain and Spinal Cord Referred Pain Visceral Pain Thermal Sensations UNIT X: The Nervous System: B. The Special Senses 50. The Eye: I. Optics of Vision Physical Principles of Optics Optics of the Eye Fluid System of the Eye—Intraocular Fluid 51. The Eye: II. Receptor and Neural Function of the Retina Anatomy and Function of Structural Elements of the Retina Photochemistry of Vision Color Vision Neural Function of the Retina 52. The Eye: III. Central Neurophysiology of Vision Visual Pathways Organization and Function of the Visual Cortex Neuronal Patterns of Stimulation During Analysis of Visual Images 53. Eye Movements and Their Control Autonomic Control of Accommodation and Pupillary Aperture Eye Movements and Their Control Autonomic Control of Accommodation and Pupillary Aperture 54. The Sense of Hearing Tympanic Membrane and the Ossicular System Cochlea Central Auditory Mechanisms UNIT XI: The Nervous System: C. Motor and Integrative Neurophysiology 55. Spinal Cord Motor Functions; The Cord Reflexes Organization of the Spinal Cord for Motor Functions Muscle Sensory Receptors—Muscle Spindles and Golgi Tendon Organs—and Their Roles in Muscle Control Flexor Reflex and the Withdrawal Reflexes Crossed Extensor Reflex Reciprocal Inhibition and Reciprocal Innervation Reflexes of Posture and Locomotion 56. Cortical and Brain Stem Control of Motor Function Motor Cortex and Corticospinal Tract Control of Motor Functions By the Brain Stem Vestibular Sensations and Maintenance of Equilibrium 57. Cerebellum and Basal Ganglia Contributions to Overall Motor Control The Cerebellum and Its Motor Functions The Basal Ganglia and Their Motor Functions Integration of the Many Parts of the Entire Motor Control System 58. Cerebral Cortex, Intellectual Functions of the Brain, Learning, and Memory Physiological Anatomy of the Cerebral Cortex Functions of Specific Cortical Areas The Corpus Callosum and Anterior Commissure Transfer Thoughts, Memories, Training, and Other Information Between the Two Cerebral Hemispheres Thoughts, Consciousness, and Memory 59. The Limbic System and the Hypothalamus—Behavioral and Motivational Mechanisms of the Brain Activating—Driving Systems of the Brain Limbic System The Hypothalamus, a Major Control Headquarters for the Limbic System Specific Functions of Other Parts of the Limbic System 60. States of Brain Activity—Sleep, Brain Waves, Epilepsy, Psychoses, and Dementia Sleep 61. The Autonomic Nervous System and the Adrenal Medulla General Organization of the Autonomic Nervous System Basic Characteristics of Sympathetic and Parasympathetic Function Selective Stimulation of Target Organs By the Sympathetic and Parasympathetic Systems or “Mass Discharge” 62. Cerebral Blood Flow, Cerebrospinal Fluid, and Brain Metabolism Cerebral Blood Flow Cerebral Microcirculation Cerebrospinal Fluid System Brain Metabolism UNIT XII: Gastrointestinal Physiology 63. General Principles of Gastrointestinal Function—Motility, Nervous and Hormonal Control, Blood Circulation, and Microbiota General Principles of Gastrointestinal Motility Neural Control of Gastrointestinal Function—Enteric Nervous System Hormonal Control of Gastrointestinal Motility Functional Movements in the Gastrointestinal Tract Gastrointestinal Blood Flow—Splanchnic Circulation Gastrointestinal Microbiota 64. Propulsion and Mixing of Food in the Alimentary Tract Ingestion of Food Motor Functions of the Stomach Movements of the Small Intestine Movements of the Colon Other Autonomic Reflexes That Affect Bowel Activity 65. Secretory Functions of the Alimentary Tract General Principles of Alimentary Tract Secretion Secretion of Saliva Gastric Secretion Pancreatic Secretion Bile Secretion By the Liver Secretion of Mucus By the Large Intestine 66. Digestion and Absorption in the Gastrointestinal Tract Digestion of Various Foods By Hydrolysis Basic Principles of Gastrointestinal Absorption Absorption in the Small Intestine Absorption in the Large Intestine and Formation of Feces 67. Physiology of Gastrointestinal Disorders UNIT XIII: Metabolism and Temperature Regulation 68. Metabolism of Carbohydrates and Formation of Adenosine Triphosphate 69. Lipid Metabolism Basic Chemical Structure of Triglycerides (Neutral Fat) Transport of Lipids in the Body Fluids 70. Protein Metabolism 71. The Liver Physiological Anatomy of the Liver Hepatic Vascular and Lymph Systems Metabolic Functions of the Liver 72. Dietary Balances; Regulation of Feeding; Obesity and Starvation; Vitamins and Minerals Energy Intake and Output Are Balanced Under Steady-State Conditions Regulation of Food Intake and Energy Storage 73. Energetics and Metabolic Rate 74. Body Temperature Regulation and Fever Normal Body Temperatures Body Temperature Is Controlled By Balancing Heat Production and Heat Loss Regulation of Body Temperature—Role of the Hypothalamus Abnormalities of Body Temperature Regulation UNIT XIV: Endocrinology and Reproduction 75. Introduction to Endocrinology Coordination of Body Functions By Chemical Messengers Chemical Structure and Synthesis of Hormones Hormone Secretion, Transport, and Clearance From the Blood Mechanisms of Action of Hormones 76. Pituitary Hormones and Their Control By the Hypothalamus Pituitary Gland and Its Relation to the Hypothalamus The Hypothalamus Controls Pituitary Secretion Physiological Functions of Growth Hormone Posterior Pituitary Gland and Its Relation to the Hypothalamus 77. Thyroid Metabolic Hormones Synthesis and Secretion of Thyroid Metabolic Hormones Physiological Functions of the Thyroid Hormones Regulation of Thyroid Hormone Secretion 78. Adrenocortical Hormones Corticosteroids: Mineralocorticoids, Glucocorticoids, and Androgens Synthesis and Secretion of Adrenocortical Hormones Functions of Mineralocorticoids—Aldosterone Functions of Glucocorticoids 79. Insulin, Glucagon, and Diabetes Mellitus Insulin and Its Metabolic Effects Glucagon and Its Functions Summary of Blood Glucose Regulation 80. Parathyroid Hormone, Calcitonin, Calcium and Phosphate Metabolism, Vitamin D, Bone, and Teeth Overview of Calcium and Phosphate Regulation in Extracellular Fluid and Plasma Bone and Its Relationship to Extracellular Calcium and Phosphate Vitamin D Parathyroid Hormone Calcitonin Summary of Control of Calcium Ion Concentration Physiology of the Teeth 81. Reproductive and Hormonal Functions of the Male (and Function of the Pineal Gland) Spermatogenesis Male Sexual Act Testosterone and Other Male Sex Hormones 82. Female Physiology Before Pregnancy and Female Hormones Physiological Anatomy of the Female Sexual Organs Female Hormonal System Monthly Ovarian Cycle and Function of Gonadotropic Hormones Functions of Ovarian Hormones—Estradiol and Progesterone Regulation of Female Monthly Rhythm—Interplay Between Ovarian and Hypothalamic-Pituitary Hormones Female Sexual Act 83. Pregnancy and Lactation Maturation and Fertilization of the Ovum Early Nutrition of the Embryo Anatomy and Function of the Placenta Hormonal Factors in Pregnancy Parturition—Birth of the Baby Lactation 84. Fetal and Neonatal Physiology UNIT XV: Sports Physiology 85. Sports Physiology | ||
| Alternate Formats: | ||
| ISBN | 9780443281099 |
| Basım Yılı | 2025 |
| Basım Sayısı | 15 |
| Sayfa Sayısı | 1200 |
| Yazar(lar) | John E. Hall,Michael E. Hall |