Diagnostic Pathology: Genitourinary, 4th Edition

• Covers more than 200 diagnoses of the kidney, bladder, prostate, testis, and penis, including new molecular markers for testing and new content on prognostic (diagnostically relevant, outcome-based) and predictive (how-to-treat and treatment-related) factors
• Provides detailed coverage of the rapid changes and continuous advances in GU cancer diagnosis, including updates on cancer research from the multiomic (or whole genome) approach, and the discovery of new cancer biomarkers
• Helps pathologists arrive at the correct diagnosis for common and uncommon lesions; identify and consider key differential diagnoses; employ judicious and contemporary ancillary studies; and generate complete, accurate surgical pathology reports using the most recent reporting guidelines
• Reflects updates to immunohistochemical information throughout for the kidney, prostate, and bladder; recent details on molecular changes for testicular tumors; and new information on the molecular aspects of tumor pathology that help make knowledge more accessible for those discussing and diagnosing at tumor board meetings
• Contains information to help pathologists understand the clinical implications of the problems, pitfalls, and applications included in AJCC cancer staging material
• Highlights current classifications of tumors of the bladder, prostate, testis, and paratestis, as well as updated general concepts regarding germ cell tumors, prostate carcinomas, squamous cell carcinomas, and urothelial carcinomas of the renal pelvis, among others
• Features a templated, highly formatted design and concise, bulleted text; diagnostic pearls, a Key Facts summary in every chapter; and an extensive index for easy reference
• Contains more than 3,800 high-quality print images (with an additional 1,400+ images as well as video content in the complimentary eBook), including gross pathology and clinical photographs, radiology and histology images, and full-color medical illustrations, carefully annotated to help you quickly recognize established entities
• Includes an eBook version that allows you access to everything in the book as well as videos and additional text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud; additional digital ancillary content may publish up to 6 weeks following the publication date

INTRODUCTION AND OVERVIEW

Introduction to Renal Cell Tumors
Classification of Kidney Tumors and Tumor-Like Lesions
Renal Cell Carcinoma: Practical Staging Considerations and Pitfalls

FAMILIAL CANCER SYNDROMES

von Hippel-Lindau Syndrome
Birt-Hogg-Dubé Syndrome
Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome
Tuberous Sclerosis Complex
Succinate Dehydrogenase Complex Deficiency Syndrome
Hereditary Papillary Renal Cancer and Miscellaneous Other Familial Cancer Syndromes
BAP1 Tumor Predisposition Syndrome

NONNEOPLASTIC LESIONS

Renal Tuberculosis, Xanthogranulomatous
Pyelonephritis, Renal Malakoplakia

RENAL CELL TUMORS, BENIGN

Papillary Adenoma
Renal Oncocytoma
Papillary Neoplasm With Reversed Polarity
Eosinophilic Vacuolated Tumor
Low-Grade Oncocytic Tumor

RENAL CELL CARCINOMA

Clear Cell Renal Cell Carcinoma
Multilocular Cystic Renal Neoplasm of Low Malignant Potential
Renal Cell Carcinoma With Fibromyomatous Stroma
ELOC (Formerly TCEB1)-Mutated Renal Cell Carcinoma
Clear Cell Papillary Renal Cell Tumor
Papillary Renal Cell Carcinoma
Chromophobe Renal Cell Carcinoma
Collecting Duct Carcinoma
SMARCB1-Deficient Renal Medullary Carcinoma and SMARCB1-Deficient Medullary-Like Renal Cell Carcinoma
TFE3-Rearranged Renal Cell Carcinoma
TFEB-Rearranged Renal Cell Carcinoma
Mucinous Tubular and Spindle Cell Carcinoma
Tubulocystic Renal Cell Carcinoma
Thyroid-Like Follicular Carcinoma of Kidney
Acquired Cystic Disease-Associated Renal Cell Carcinoma
Somatic Fumarate Hydratase-Deficient Renal Cell Carcinoma
ALK Rearrangement-Associated Renal Cell Carcinoma
Eosinophilic Solid and Cystic Renal Cell Carcinoma
Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma
Subsequent 2nd Tumors
Renal Cell Carcinoma, Not Otherwise Specified

METANEPHRIC TUMORS

Metanephric Adenoma
Metanephric Tumors Other Than Metanephric Adenoma

NEPHROBLASTIC TUMORS

Nephrogenic Rests
Nephroblastoma (Wilms Tumor)
Cystic Partially Differentiated Nephroblastoma

MESENCHYMAL TUMORS

Angiomyolipoma
Epithelioid Angiomyolipoma/Epithelioid PEComa
Congenital Mesoblastic Nephroma
BCOR-Rearranged and Clear Cell Sarcoma of Kidney
Rhabdoid Tumor of Kidney
Anaplastic Sarcoma of Kidney

MIXED MESENCHYMAL AND EPITHELIAL TUMORS

Mixed Epithelial and Stromal Tumor (MEST) Family Tumors
Pediatric Cystic Nephroma
Synovial Sarcoma

NEUROENDOCRINE TUMORS

Renal Neuroendocrine Tumor/Carcinoid Tumor and Neuroendocrine Carcinoma
Renal Ewing Sarcoma

HEMATOPOIETIC TUMORS

Hematopoietic Tumors
METASTATIC AND OTHER TUMORS

Juxtaglomerular Cell Tumor (Reninoma)
Renomedullary Interstitial Cell Tumor
Other Rare Tumors
Metastatic Tumors

IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING KIDNEY

Immunohistochemistry, Kidney

SECTION 2: URINARY TRACT

INTRODUCTION AND OVERVIEW

Classification of Bladder Tumors and Tumor-Like Lesions
Bladder Cancer: Practical Staging Considerations and Pitfalls
Renal Pelvis: Practical Staging Considerations and Pitfalls

MICROSCOPIC ANATOMY

Microscopic Anatomy of Urinary Bladder
Microscopic Anatomy of Urethra
Microscopic Anatomy of Ureter
Microscopic Anatomy of Renal Pelvis

NONNEOPLASTIC LESIONS OF URINARY TRACT

Overview of Cystitis
Polypoid Cystitis
Malakoplakia
Schistosomiasis
von Brunn Nests
Nephrogenic Adenoma (Metaplasia)
Fibroepithelial Polyp
Prostatic-Type Polyp (Ectopic Prostate)
Amyloidosis
Müllerian Lesions
Pseudocarcinomatous Hyperplasia
Hamartoma

UROTHELIAL NEOPLASMS, GENERAL

Overview of Urinary Bladder Neoplasms

FLAT UROTHELIAL LESIONS

Urothelial Carcinoma In Situ
Flat Urothelial Lesions Other Than Carcinoma In Situ

UROTHELIAL NEOPLASMS, NONINVASIVE

Atypical Urothelial Proliferations, Flat and Tented Type (Formerly Flat and Papillary Hyperplasia)
Urothelial Papilloma
Papillary Urothelial Neoplasm of Low Malignant Potential
Low-Grade Papillary Urothelial Carcinoma
High-Grade Papillary Urothelial Carcinoma
Inverted Urothelial Neoplasia

UROTHELIAL NEOPLASMS, INVASIVE

Invasive Urothelial Carcinoma
Urothelial Carcinoma, Subtypes and Divergent Differentiation

GLANDULAR LESIONS

Cystitis Cystica et Glandularis
Villous Adenoma
Invasive Adenocarcinoma
Clear Cell Adenocarcinoma

SQUAMOUS LESIONS

Squamous Proliferations Other Than Carcinoma
Invasive Squamous Cell Carcinoma

MESENCHYMAL LESIONS

Myofibroblastic Proliferations
Smooth Muscle Tumors
Rhabdomyosarcoma
Other Mesenchymal Tumors

OTHER TUMORS OF URINARY BLADDER

Paraganglioma
Metastatic/Secondary Involvement of Bladder

DIVERTICULA OF URINARY TRACT

Diverticula
Diverticular-Associated Neoplasia

URETHRA

Inflammatory Lesions of Urethra
Carcinoma of Urethra
Other Tumors and Tumor-Like Lesions of Urethra

URETER

Urothelial Carcinoma of Ureter
Other Tumors and Tumor-Like Lesions of Ureter

RENAL PELVIS

Urothelial Carcinoma of Renal Pelvis
Other Tumors and Tumor-Like Lesions of Renal Pelvis

URACHUS

Urachal Remnants
Tumors of Urachus

IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING URINARY BLADDER

Immunohistochemistry, Urinary Tract

SECTION 3: PROSTATE GLAND AND SEMINAL VESICLE

INTRODUCTION AND OVERVIEW

Classification of Prostate Tumors and Tumor-Like Lesions
General Concepts, Prostate
Microanatomy and Zonal Variations
Imaging Considerations for Pathologists
Prostate: Practical Staging Considerations and Pitfalls

NONNEOPLASTIC LESIONS

Prostatitis
Prostate Hyperplasia
Adenosis
Atrophy and Its Patterns
Hyperplasia of Mesonephric Remnants
Verumontanum Mucosal Gland Hyperplasia
Nephrogenic Adenoma (Metaplasia) of Prostatic Urethra

PUTATIVE PREMALIGNANT LESIONS AND LESIONS FALLING SHORT OF MALIGNANT DIAGNOSIS

Prostatic Intraepithelial Neoplasia

PROSTATE NEOPLASMS

General Concepts, Prostate Carcinoma
Acinar Adenocarcinoma
Acinar Adenocarcinoma Subtypes and Patterns
Atypical Small Acinar Proliferations
Intraductal Carcinoma and Other Intraductal Proliferations
Ductal Adenocarcinoma
Urothelial Carcinoma Involving Prostate Gland
Prostate Carcinoma With Neuroendocrine Differentiation
Adenoid Cystic (Basal Cell) Carcinoma of Prostate
Sarcomatoid Carcinoma of Prostate
Carcinomas With Squamous Differentiation
Cystic Epithelial Tumors of Prostate
Stromal Tumors
Mesenchymal Tumors of Prostate
Melanocytic Lesions of Prostate
Hematopoietic Neoplasms of Prostate
Secondary Tumors of Prostate

TUMORS OF SEMINAL VESICLE

Mixed Epithelial and Stromal Tumor
Seminal Vesicle Adenocarcinoma

IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS AND TUMOR-LIKE LESIONS INVOLVING PROSTATE GLAND

Immunohistochemistry, Prostate

SECTION 4: TESTIS AND PARATESTICULAR STRUCTURES

INTRODUCTION AND OVERVIEW

Classification of Testis and Paratestis Tumors and Tumor-Like Lesions
Testicular Tumors: Practical Staging Considerations and Pitfalls

NONNEOPLASTIC LESIONS

Cryptorchidism
Sertoli Cell-Only Syndrome
Nontuberculous Infections
Nonspecific Granulomatous Orchitis
Tuberculous Epididymo-Orchitis

GERM CELL TUMORS

General Concepts, Germ Cell Tumors

GERM CELL TUMORS RELATED TO GERM CELL NEOPLASIA IN SITU

Germ Cell Neoplasia In Situ
Seminoma
Intratubular Seminoma
Intratubular Embryonal Carcinoma
Embryonal Carcinoma
Yolk Sac Tumor
Choriocarcinoma and Other Trophoblastic Tumors
Postpubertal-Type Teratoma
Mixed Germ Cell Tumors
Somatic-Type Malignancy in Germ Cell Tumor
Burnt-Out (Regressed) Germ Cell Tumor

GERM CELL TUMORS UNRELATED TO GERM CELL NEOPLASIA IN SITU

Spermatocytic Tumor
Pediatric Germ Cell Tumor, General Concepts
Prepubertal-Type Teratoma
Yolk Sac Tumor, Prepubertal Type
Mixed Teratoma and Yolk Sac Tumor, Prepubertal Type
Well-Differentiated Neuroendocrine Tumor (Monodermal Teratoma)

SEX CORD-/GONADAL STROMAL TUMORS

General Concepts, Sex Cord-/Gonadal Stromal Tumors
FH-Deficient Leydig Cell Tumors
Leydig Cell Tumors
Sertoli Cell Tumors
Large Cell Calcifying Sertoli Cell Tumor
Intratubular Large Cell Hyalinizing Sertoli Cell Tumor
Granulosa Cell Tumor
Juvenile Granulosa Cell Tumor
Fibroma-Thecoma
Myoid Gonadal Stromal Tumor
Signet-Ring Stromal Tumors
Nested Sex Cord-Stromal Tumor
Testicular Tumor of Adrenogenital Syndrome
Sex Cord-Stromal Tumor, Mixed/Unclassified
Gonadoblastoma

HEMATOPOIETIC TUMORS

Lymphoma/Leukemia/Plasmacytoma

TUMORS OF PARATESTICULAR STRUCTURES

Adenomatoid Tumor
Well-Differentiated Papillary Mesothelial Tumor
Malignant Mesothelioma
Adenocarcinoma of Rete Testis/Epididymis
Epididymal Tumors
Ovarian Epithelial-Type Tumors
Liposarcoma
Melanotic Neuroectodermal Tumor
Rhabdomyosarcoma
Other Sarcomas

METASTATIC TUMORS, TESTIS AND PARATESTICULAR STRUCTURES

Metastatic Tumors, Testis and Paratesticular Structures

IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING TESTIS AND PARATESTICULAR STRUCTURES

Immunohistochemistry, Testis

SECTION 5: PENIS AND SCROTUM

FREQUENT LESIONS OF UNCERTAIN RELATIONSHIP TO PENILE NEOPLASIA

Condyloma
Lichen Sclerosus
Squamous Hyperplasia
Lipogranuloma
Scrotal Calcinosis

PENILE INTRAEPITHELIAL NEOPLASIA

Penile Intraepithelial Neoplasia

PRIMARY EPITHELIAL TUMORS

General Concepts, Squamous Cell Carcinoma (Including Staging and Molecular Pathology)
Overview of HPV- and Non-HPV-Related Tumors
Carcinoma of Penis: Practical Staging Considerations and Pitfalls

SQUAMOUS CELL CARCINOMA AND ITS SUBTYPES

Squamous Cell Carcinoma, Usual Type
Basaloid Squamous Cell Carcinoma
Basaloid Squamous Cell Carcinoma, Papillary Subtype
Warty (Condylomatous) Squamous Cell Carcinoma
Warty-Basaloid Squamous Cell Carcinoma
Verrucous Squamous Cell Carcinoma
Papillary Squamous Cell Carcinoma, Not Otherwise Specified
Pseudoglandular Squamous Cell Carcinoma
Pseudohyperplastic Squamous Cell Carcinoma
Cuniculatum Squamous Cell Carcinoma
Sarcomatoid Squamous Cell Carcinoma
Mixed Squamous Cell Carcinoma
Undifferentiated to Poorly Differentiated Squamous Cell Carcinomas With Prominent Inflammatory Infiltrate
Clear Cell Carcinoma

OTHER NEOPLASTIC CONDITIONS

Extramammary Paget Disease
Kaposi Sarcoma
Myointimoma

METASTATIC TUMORS

Metastatic Tumors, Penis

IMMUNOHISTOCHEMICAL PROFILES FOR TUMORS INVOLVING PENIS

Immunohistochemistry, Penis