Toxicologic Pathology: Nonclinical Safety Assessment 3rd Edition

The new edition provides practical and timely information for toxicologic pathologists working in drug discovery and development. The introductory concept chapters are consolidated into two more concise and better-organized introductory chapters. The two concept chapters introduce the reader to pharmaceutical R&D, the role of the pathologist in the process, and critical partner scientific disciplines with whom the pathologist will collaborate. In this revision, the organ system chapters incorporate more consistent commentary and guidance on the molecular mechanism of action, human translational relevance, and regulatory impact of pathological findings as they are described in these chapters.

Key Features:

• Aids scientists in understanding spontaneously occurring and compound-related pathological findings
• Features three new well-respected scientists on the editorial team
• Includes more consistent commentary and guidance in the organ system chapters

Chapter 1. Nonclinical Safety Assessment: An Overview of Drug and Medical Device Development
Thomas M. Monticello, Timothy MacLachlan, Kathleen A. Funk, Brooke M. Rock, Jeanine L. Bussiere, Jessica Grieves, JoAnne C.L. Schuh, and Scott Henry

Chapter 2. Toxicologic Anatomic Pathology and the Pathologist
Vanessa L. Schumacher, Christopher J. Clarke, Robert C. Johnson, Arun R. Pandiri, and Daniel J. Patrick

Chapter 3. Toxicologic Clinical Pathology
Niraj K. Tripathi

Chapter 4. Gastrointestinal System
Thomas Nolte, Jagannatha Mysore, Arlin Rogers, and Johannes Junginger

Chapter 5. Hepatobiliary System and Exocrine Pancreas
Arun R. Pandiri, Barbara Lenz, and Christopher D. Houle

Chapter 6. Respiratory System
Tom P. McKevitt and Nicholas Macri

Chapter 7. Urinary System
Kendall S. Frazier and John Curtis Seely

Chapter 8. Hematopoietic System
Kristin L. Henson, Tanasa S. Osborne, Allison Vitsky, and Adi Wasserkrug-Naor

Chapter 9. Lymphoid System
Patrick Haley

Chapter 10. Musculoskeletal System and Teeth
Kathryn E. Gropp, Agathe Bédard, Stacey Fossey, D. Greg Hall, and Ryan M. Schafbuch

Chapter 11. Cardiovascular System
Ronnie Chamanza, Chidozie Amuzie, David Brott, and Calvert Louden

Chapter 12. Endocrine System
Richard A. Peterson, Christopher Houle, and Raju Mantena

Chapter 13. Reproductive System and Mammary Gland
Justin D. Vidal, Sarah Coe, Karyn Colman, Kiran Palyada, Cynthia J. Willson, and Charles E. Wood

Chapter 14. Integumentary System
Zbigniew W. Wojcinski, Lydia Andrews-Jones, Daher Ibrahim Aibo, Rie Kikkawa, Sheila Cummings, and Robert Dunstan

Chapter 15. Nervous System
Sarah D. Cramer, Alys Bradley, and Mark T. Butt

Chapter 16. Special Senses: Eye and Ear
Vanessa Vrolyk, Kenneth A. Schafer, Oliver C. Turner, Helen S. Booler, and Richard A. Altschuler