Covering all the basic and clinical concepts you need to know for your coursework and USMLEs, Immunology, 9^th Edition, offers a well-illustrated, carefully structured approach to this complex and fast-changing field. Carefully edited and authored by experts in both teaching and research, it provides cutting-edge, consistent coverage that links the laboratory and clinical practice. A user-friendly, color-coded format, including key concept boxes, explanatory diagrams, and nearly 200 photos to help you visually grasp and retain challenging concepts.

• • Explains the building blocks of the immune system - cells, organs, and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context.

• • Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more.

• • Features a reorganized format that presents immunology in the order in which is typically taught and learned, better integrating basic and clinical immunology.

• • Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer.

• • Provides Critical Thinking boxes, chapter-opening summaries, and case-based and USMLE-stylesss questions that provide effective review and quick practice for exams – plus more learning opportunities online, including USMLE-stylesss questions and clinical cases.

• Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. It also features full color 3-D animations to deliver a dynamic visual overview of immunological concepts.

Includes extensive updates to clinical information, including recent clinical approaches in cancer immunology, transplantation, autoimmunity, hypersensitivity, and more.

Covers new topics such as innate lymphoid cells, antibody-based therapies and antibody engineering, innate immunity and its components, the genetics of immunologically-based diseases and personalized medicine, and immunotherapeutic agents for the treatment of cancer.

Table of Contents:

SECTION 1 The Immune System and Innate Immunity

1 Introduction to the Immune System

2 Cells, Tissues and Organs of the Immune System

3 Mechanisms of Innate Immunity

4 Complement

5 Mononuclear Phagocytes in Immune Defence

SECTION 2 Adaptive Immune Responses

6 T-Cell Receptors and Major Histocompatibility Complex Molecules

7 Antigen Presentation

8 Cell-Mediated Cytotoxicity

9 B-Cell Development and the Antibody Response

10 Antibodies

11 Immunological Tolerance

12 Regulation of the Immune Response

13 Immune Responses in Tissues

SECTION 3 Defence Against Infectious Agents

14 Immunity to Viruses

15 Immunity to Bacteria and Fungi

16 Immunity to Protozoa and Worms

17 Vaccination

SECTION 4 Immunodeficiency

18 Primary Immunodeficiencies

19 AIDS, Secondary Immunodeficiency and Immunosuppression

SECTION 5 Immune Responses Against Tissues

20 Autoimmunity and Autoimmune Disease

21 Transplantation and Rejection

22 Immunity to Cancers

SECTION 6 Hypersensitivity

23 Immediate Hypersensitivity (Type I)

24 Hypersensitivity (Type II)

25 Hypersensitivity (Type III)

26 Hypersensitivity (Type IV)