Glaucoma, 3rd Edition

• Covers the latest updates in the field, including minimally invasive glaucoma surgery and micro-stent innovation; advances in diagnostic imaging, including OCT; gene therapy, stem cell research, and regenerative approaches; medical therapies, including cost-effective strategies; management of co-existing cataract and glaucoma; and core surgical techniques such as trabeculectomy, non-penetrating glaucoma surgeries, glaucoma drainage device implantation, and more
• Contains sixteen new chapters, including Metabolism, Ageing, and Glaucoma Pathogenesis; OCTA in Glaucoma Diagnosis; Sustained Delivery Systems for Glaucoma Medications; Marijuana and Glaucoma; Laser as First Line Treatment; Micro-invasive Bleb Surgery (MIBS); and more, as well as new chapters on big data, lifestylesss changes, alternative therapies, VR devices, telemedicine, and artificial intelligence
• Helps you refine your diagnostic and surgical skills with more than 1,600 illustrations, photos, and graphics that capture essential diagnostic techniques, imaging methods, and surgical approaches
• Features a refreshed video collection of more than 50 video clips that depict the latest techniques and procedures including: new trabeculectomy methods, needling, implants, valve complications, and more
• Includes spotlight commentaries from key leaders that provide added insight, tips, and pearls across varying hot topics and advances in the field
• An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

Section 1 Glaucoma in the World
1. Prevalence and Geographic Variations
Winnie Nolan, Jennifer LY Yip, Nicolas Winklmair, Katharina Cornelia Bell
Spotlight: China Study
JOST B JONAS
Spotlight: What Do Prevalence and Geographic Variations Tell Us?
KAZUHISA SUGIYAMA and FARRAH JA’AFAR
2. Screening for Glaucoma
Paul Healey
Spotlight: Screening in Africa
DAN KIAGE

Section 2 Pathogenesis
3. Aqueous Humor Dynamics and Intraocular Pressure Elevation
Carol B. Toris
4. Pathogenesis of Glaucomatous Optic Neuropathy
James E. Morgan
5. Mechanical Strain and Restructuring of the Optic Nerve Head
J Crawford Downs and Alireza Karimi
6. Role of Vascular Blood Flow in the Pathogenesis of Glaucoma
Ali S. Hafez and Mark Richard Lesk
7. Metabolism, Ageing, and Glaucoma Pathogenesis
Pete A. Williams and Jonathan Crowston

Section 3 Evaluation of Glaucoma
8. Tonometry and Intraocular Pressure Fluctuation
Soledad Aguilar-Munoa, Kin Sheng Lim and David Garway-Heath
Spotlight: Tonometry and Intraocular Fluctuation
Hassan El Daly
9. Visual Fields
David P. Crabb and Pete R. Jones
10. Long Term Follow-Up of Visual Fields
Balwantray Chauhan and Rizwan Malik
11. Function-Specific Perimetry
Felipe Medeiros, Alessandro Adad Jammal and Jonathan Crowston
12. New Approaches to Perimetry
Alessandro Adad Jammal and Felipe Medeiros
13. Electrophysiology in Glaucoma Assessment
Stuart Graham and Brad Fortune
14. Gonioscopy
John Frank Salmon
15. Ultrasound Biomicroscopy and Angle Imaging
Giorgio Marchini, Piero Ceruti and Ottavia Albertini
16. Angle Imaging: Anterior Segment Optical Coherence Tomography
Gus Gazzard, Winnie Nolan and Pavi Agrawal
17. Corneal Biomechanics in Glaucoma
James D. Brandt, Sean McCafferty and Cynthia J. Roberts
Spotlight: What a Glaucoma Specialist Needs to Know About Corneal Biomechanics
ZISIS Gatzioufas and FARHAD HAFEZI
Spotlight: Measuring Corneal Biomechanics in the Clinic
CHRISTOPHER KS LEUNG
Spotlight: New Technology to Look at Corneal Biomechanics in Clinic
ZISIS Gatzioufas
18. Optic Disc Photography in Diagnosis of Glaucoma
Jonas Bruno Jost and Alain M. Bron
Spotlight: Benchmarking Optic Disc Examination
MICHAEL A COOTE and JONATHAN G CROWSTON
Spotlight: Optic Disc Photography in the Diagnosis of Glaucoma
REMO SUSANNA JR.
19. Optic Disc Imaging
Nevin El-Nimri, Christopher Bowd, Felipe Medeiros and Linda M. Zangwill
20. Retinal Nerve Fiber Layer Analysis
Howard Barnebey, Neil T. Choplin and Anna Thanh Tam Do
21. Optical Coherence Tomography Angiography in Glaucoma Diagnosis (OCTA)
Magdy Moussa, Mahmoud Leila and Omar Moussa
22. Measuring Glaucoma Progression in Clinical Practice
Alessandro Rabiolo, Lourdes Grassi and Joseph Caprioli
23. Genetics of Glaucoma
Janey Wiggs
Spotlight: Japanese Perspective
FUMIHIKO MABUCHI
24. Genetic Epidemiology
Ananth Viswanathan
Spotlight: Family Screening for Glaucoma
DAVID A MACKEY
Spotlight: Boston Studies
LOUIS R PASQUALE

Section 4 Types of Glaucoma
25. Ocular Hypertension
Sophia Y. Wang and Kuldev Singh
26. Primary Open-Angle Glaucoma
Albert S. Khouri and Robert D. Fechtner
27. Normal Tension Glaucoma
Angelo Peter Tanna
Spotlight: Japanese Perspective
YOSHIAKI KIUCHI
Spotlight: Korean Perspective
KI HO PARK
28. Exfoliation Syndrome and Exfoliative Glaucoma
Robert Ritch and Ursula Schlötzer-Schrehardt
29. Pigmentary Glaucoma
Stefano Gandolfi, Nicola Ungaro, Luigi Varano, Viola Tagliavini and Paolo Mora
Spotlight: Iridotomy for Pigmentary Glaucoma
FOTIS TOPOUZIS
30. Primary Angle-Closure Glaucoma
Paul J. Foster, Wai Siene Ng and Luke Tanner
Spotlight: Angle Closure
MONISHA E NONGPIUR, ERANGA N VITHANA and TIN AUNG
31. Secondary Angle-Closure Glaucoma
Chaiwat Teekhasaenee, Syril Dorairaj, Robert Ritch
32. Neovascular Glaucoma
Annapurna Singh and Kevin Halenda
33. Uveitic Glaucoma
Avinash Kulkarni and Keith Barton
Spotlight: Uveitic Glaucoma
JOSEPH R ZELEFSKY and EMMETT T CUNNINGHAM JR.
34. Glaucoma Secondary to Trauma
Kaweh Mansouri, Bahaa N. Noureddine and Tarek Shaarawy
Spotlight: Surgical Management of Post-Traumatic Angle-Recession Glaucoma
JOHN F SALMON
35. Glaucoma and Intraocular Tumors
Vishal K. Patel, Annapurna Singh, Arun D Singh
36. Glaucoma in the Phakomatoses and Related Conditions
Chaiwat Teekhasaenee and Robert Ritch
37. Other Secondary Glaucomas
Jody R. Piltz-Seymour, Tania Tai and Roxanne Lee
38. Childhood Glaucomas
Annette Giangiacomo and Allen Beck

Section 5 Principles of Management
39. Management of Ocular Hypertension and Primary Open-angle Glaucoma
Roger Hitchings, Emily Dawson and Mark Sherwood
40. An Overview of Angle-Closure Management
Chaiwat Teekhasaenee
Spotlight: An Overview of Angle-Closure Management
CHELVIN CA SNG and PAUL TK CHEW
Spotlight: Cataract and Clear Lens Extraction
MARK J WALLAND
41. Quality of Life
Panayiota Founti, Alexander Spratt, Aachal Kotecha, and Ananth C Viswanathan
42. Optimizing Patient Outcomes in Glaucoma: Effectiveness of Glaucoma Treatments on Quality of Life
Preeti Gupta, Kam Chun Ho, Ryan EK Man and Ecosse L. Lamoureux
Spotlight: Evaluation of Quality of Life
ECOSSE L LAMOUREX and EVA FENWICK
43. Ocular Hypotensive Medications: Adherence and Performance
Gary D. Novack, Kelly W. Muir, Paula Anne Newman Casey and Alan L. Robin
44. Outcomes - Goals of Treatment
Ivan Goldberg, Ridia Lim and Colin Clement
45. Benefit Versus Risk
Ravi Thomas, Rajul S. Parikh and Shefali R. Parikh

Section 6 Medical Therapy
46. Prostagladin Analogues
Norbert Pfeiffer
47. Beta-blockers
Ingeborg Stalmans, Ann M. Hoste, Sophie Lemmens and Evelien Vandewalle
Spotlight: Alternate View
Anthony REALINI
48. Carbonic Anhydrase Inhibitors
Gábor Holló
49. Alpha Agonists
Adam C. Reynolds
50. Rhokinase
Janet B. Serle and Jake Edward Radell
51. Parasympathomimetics
Lineu Oto Shiroma, Vital Paulino Costa and Fernanda Nodari Ferreira
52. Fixed Combination Therapies in Glaucoma
Anastasios G. Konstas and Andreas Katsanos
53. Ocular Surface Disease and the Role of Preservatives in Glaucoma Medications
Malik Kahook, Sabita M. Ittoop and Leonard Seibold
54. Sustained delivery systems for Glaucoma Medications
Ian Pitha
55. Marijuana and Glaucoma
Helen Danesh-Meyer
56. Management of Acute Intraocular Pressure Rise
Prin Rojanapongpun, Visanee Tantisevi and Orathai Chansanti

Section 7 Surgery: Introduction
57. Laser as First Line Treatment
Tony Realini and Gus Gazzard
58. Surgery as First Line Treatment
Jamie Lea Schaefer and Mark Sherwood
59. The Trabecular Meshwork Outflow Pathways: Surgical Aspects
Ernst Tamm

Section 8 Laser Therapy
60. Selective Laser Trabeculoplasty
Samer Abuswider, Karim Fatehali Damji and Robert Ritch
Spotlight: Long-Term Effects
IVAN GOLDBERG
Spotlight: Selective Laser Trabeculoplasty
MICHAEL WAISBOURD and L JAY KATZ
61. Peripheral Iridotomy for Angle-Closure Glaucoma
Clement CY THAM, Dennis SC Lam, Poemen PM Chan and Thomas C. Lam
62. Laser Peripheral Iridoplasty
Chaiwat Teekhasaenee

Section 9 Trabeculectomy
63. Ophthalmic Anesthesia
Douglas J. Rhee, Yasemin Sozeri, Stephen Lau and Meenakashi Gupta
64. Trabeculectomy: Preoperative Evaluation and Management
Nuwan Niyadurupola and David C. Broadway
65. Trabeculectomy
Ronald Leigh Fellman and Davinder S. Grover
Spotlight: Trabeculectomy
LOUIS PASQUALE
Spotlight: Releasable Sutures
MARK B SHERWOOD
Spotlight: Anterior Chamber Maintainer
ELIE DAHAN
66. Wound Healing and Bleb Evaluation after Trabeculectomy
Anthony Wells and Jonathan Crowston
Spotlight: Histology of the Mature Functioning and Leaking Bleb
TERUHIKO HAMANAKA
67. Intraoperative Complications of Trabeculectomy
James C. Tsai, Rajendra K. Bansal and Daniel S. Casper
68. Early Postoperative Increase in Intraocular Pressure
Pratap Challa
69. Tenon’s Cyst Formation and Management
Anthony Wells
70. Postoperative Shallow Anterior Chamber
Anil K. Mandal, Debasis Chakrabarti and Raka Chatterjee
71. Aqueous Misdirection
Pradeep Y. Ramulu and Dave Pujan
72. Choroidal Effusion and Hemorrhage
Steven L. Mansberger and Bennett Y. Hong
73. Late Bleb Leaks and Complications Associated with Modulation of Wound Healing in Glaucoma Surgery
Jacob Wilensky
74. Blebitis and Endophthalmitis
Peter Shah, Mark Chiang and Graham Lee
75. Late Hypotony
John Thygesen
76. Late Failure of Filtering Bleb
Aiyin Chen and Robert L. Stamper
77. Cataract Following Trabeculectomy
Alain M. Bron, Aptel Florent and Antoine Labbe
78. Trabeculectomy-related Corneal complications
Fathi F El Sayyad, Magdy Nofal and Fouad E. Sayyad

Section 10 Nonpenetrating Glaucoma Surgery
79. Non-Penetrating Procedures - Principle and Mechanism of Function
Omar Magdy Khaled
80. Deep Sclerectomy and Postoperative Management of Nonpenetrating Glaucoma Surgery
André Mermoud, Shibal Bhartiya, Tarek Shaarawy
Spotlight: Implants in Deep Sclerectomy
SERGIO ESTRELA SILVA
Spotlight: Non-Stitch Suprachoroidal Technique for T-flux Implantation in Deep Sclerectomy
GONZALO MUÑOZ
Spotlight: Enhancing Deep Sclerectomy Result with Antimetabolites
NITIN ANAND
Spotlight: If Primary Deep Sclerectomy Fails
SHIBAL BHARTIYA
81. Results of Nonpenetrating Glaucoma Surgery
Daniel E. Grigera, Jorge Eduardo Acosta Sr. and Virginia Zanutigh
Spotlight: Nonpenetrating Surgery: When is this my Preferred Option?
STEFANO A GANDOLFI

Section 11 Modulation of Wound Healing
82. Risk factors for excess wound healing
Arvind Neelakantan, Richard Parrish II and Rebecca Chen
83. Modulation of Wound Healing
Christophe Baudoin and Antoine Labbé
84. Biological Drivers of Postoperative Scarring and Future Strategies
Sonal S. Tuli, Sir Peng Tee Khaw, Gregory S. Schultz, Yasmin Islam and Mark Sherwood
85. Bleb Needling and Enhancement
Ann Caroline Fisher, Robert T. Chang, Kuldev Singh and Suria Sudhakaran Mannil

Section 12 Management of Co-Existing Cataract and Glaucoma
86. Cataract Surgery in Open Angle Glaucoma
Michael A. Coote and Bob Wang
87. The Role of Lens Extraction in Primary Angle Closure Glaucoma
Augusto Azuara-Blanco and Gerard Reid
88. Goniosynechialysis
Chaiwat Teekhasaenee
89. Cataract Surgery in Patients with Functioning Filtering Blebs
Franz Grehn and Thomas Klink
Spotlight: Bleb Management
ALAN S CRANDALL
90. Combined Phaco and MIGS
Eric Grieser and Aaron Webel
91. Combined Sugery: Phacotrabeculectomy
Yvonne M. Buys and David J. Mathew
92. Combined cataract extraction and glaucoma drainage implant surgery
Vital Paulino Costa

Section 13 Drainage Devices
93. Preoperative Evaluation of Patients Undergoing Drainage Implant Surgery and Choice of Implant
Jeffrey Freedman V and Keith Barton
94. Glaucoma Drainage Implants - Surgical Technique
Kin Sheng Lim and Sylvia Linner Groth
Spotlight: Venting Slits for Non-Valved Tubes
MARK SHERWOOD
Spotlight: Operative Techniques and Potential Modifications
DON MINCKLER
95. Aqueous Shunts after Retinal Surgery
Keith Barton and Maria Papadopoulos
96. Intraoperative Complications and Postoperative Complications
Ronald L. Gross, Louis B. Cantor, Peter Chang and Trenton Bowen
97. Glaucoma Implants: Results from Clinical Trials
Alejandra Hernandez-Oteyza, Oscar Albis-Donado and Steven Gedde
Spotlight 97.1. TVT Study STEVEN J GEDDE
Spotlight 97.2. Engineering Outflow MICHAEL COOTE
98. Aqueous Shunts and the Cornea
Catherine R. Sheils, Etsuo Chihara, Donald Saier Minckler and Sameh Mosaed

Section 14 Surgery for Congenital Glaucoma
99. Goniotomy and Trabeculotomy
Sir Peng Tee Khaw, Alessandra Martins, Franz Grehn and Keith Barton
100. Further Surgical Options in Children
Mark Werner, Alana Grajewski and Elena Bitrian

Section 15 Procedures that Target the Ciliary Body
101. Cyclodestructive Techniques
Philip A. Bloom and Laura Crawley
Spotlight: Operative Techniques
DAVID C BROADWAY
Spotlight: Postoperative Management and Interventions
DAVID C BROADWAY
Spotlight: Retreatment and Further Postoperative Care
STEPHEN A VERNON
Spotlight: UC3 Novel Ultrasound Circular Cyclo-Coagulation
PHILIPPE DENIS
102. Endophotocoagulation
Stanley J. Berke, MD, FACS, Valentina Lozano and Daniela Alvarez-Ascencio
Spotlight: PHACO-ECP
PIETER GOUWS
103. Complications of Cyclodestructive Procedures
Malik Kahook, Chisom T. Madu and Joel S. Schuman
Spotlight: Transscleral Diode in Patients with Good Vision
STEPHEN A VERNON
Spotlight: Sympathetic Ophthalmia
ANNIE K BAIK and JAMES D BRANDT

Section 16 MIGS
104. Canal Based Procedures
Zeynep Aktas and Ahmet Yucel Ucgul
105. Canal based Devices
Norbert Pfeiffer
106. Suprachoroidal Space Based Procedures
Philippe Denis
107. Subconjunctival Based MIGS Procedures
Tarek Shaarawy, Bahaa N. Noureddine, Kaweh Mansouri and Kevin Gillmann

Section 17 New Developments in Glaucoma
108. Neuroprotection, Neuroenhancement, and Neuroregeneration
Leonard A. Levin
109. RGC replacement
Thomas V. Johnson III and Erika A. Aguzzi
110. Big Data and Glaucoma
Randy Lu, Andrew Chen and Aaron Yuntai Lee
111. Lifestylesss Changes in Glaucoma
Louis R. Pasquale and Sefy A. Paulose
112. Meditation and Alternative Therapies for Glaucoma
Tanuj Dada
113. Smartphone and Virtual Reality Devices in Glaucoma screening and detection
Parul Ichhpujani and Sahil Thakur
114. Telemedicine and Glaucoma
Rahat Husain, Dawn A. Sim and Bonnie Choy
115. AI and Glaucoma
Mingguang He, Yixiong Yuan and Danli Shi