Modern Diabetology Basic Science and Clinical Practice

• Provides up-to-date coverage of basic science, translational advances, and clinical management in one accessible text, serving as a critical reference for practitioners navigating fast-moving developments in the field
• Features 24 chapters authored by internationally recognized experts in diabetes research and clinical practice
• Offers in-depth updates on rapidly advancing areas including MODY, hormonal biology, Types 1 and 2 diabetes genetics, immune mechanisms, and oxidative stress and complications
• Covers cutting-edge therapeutic strategies such as SGLT2 inhibitors, GLP1 - receptor agonists, glucose sensors and pumps, stem cell therapy, and pancreas and islet transplantation
• An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date

Section I: Regulation of Gene Expression, Hormone Synthesis, Hormone Secretion
1. Pancreatic Development in the Context of Diabetes
2. Glucagon: From Gene Regulation to Secretion
3. Insulin Production, Processing, and Secretion
4. Incretins: From Gene Expression to Secretion and Action of GLP-1 and GIP

Section II: Hormone Action
5. Glucagon Synthesis, Secretion and Mechanisms of Action
6. Insulin Structure and Function
7. Common Mechanisms of Insulin Signaling, Action, and Resistance
8. Insulin Receptor Structure and Function
9. Insulin Action in Liver, Skeletal, Muscle, and Adipose Tissue: A Focus on Humans
10. Insulin Action in the Brain
11. Insulin Action in the Cardiovascular System
12. Metabolic Regulation by Adipokines, Hepatokines, and Myokines

Section III: Genetics of Diabetes
13. Genetics of Monogenic Forms of Diabetes
14. Genetics of Type 1 Diabetes
15. Genetics of Type 2 Diabetes

Section IV: Type 1 Diabetes
16. Spotlight on the Pathology of Type 1 Diabetes

Section V: Type 2 Diabetes
17. Heterogeneity of Type 2 Diabetes Mellitus
18. Cystic Fibrosis Related Diabetes

Section VI: Complications of Diabetes
19. Intranuclear Beta Cell Nrf2 EDxpression in Type 2 Diabetes and the Potential Use of Glutathione Peroxidase Mimetics for Early Treatment
20. Diabetic Retinal Disease
21. Understanding Diabetic Neuropathy: From Pathophysiology to Therapeutic Targets

Section VII: Pharmacology and Drugs
22. SGLT2 Inhibitors and Slowing Kidney Disease Progression from Diabetes
23. Advanced Technology in Diabetes: Sensors and Pumps
24. Pancreas and Islet Cell Transplantation for Diabetes
25. Stem Cell-Derived Islet Therapy for Type 1 Diabetes